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Symbol
Name
ID
Stk4
serine/threonine kinase 4
MGI:1929004
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations

Mouse Phenotypes
increased T cell apoptosis
abnormal leukocyte migration
abnormal leukocyte adhesion
increased T cell proliferation
thymus hyperplasia
increased thymocyte number
abnormal T cell differentiation
abnormal CD4-positive T cell differentiation
increased neutrophil cell number
decreased CD11b-high dendritic cell number
decreased myeloid dendritic cell number
increased dendritic cell number
decreased B-1 B cell number
decreased B-2 B cell number
decreased marginal zone B cell number
increased B-1b cell number
decreased B cell number
increased NK cell number
increased central memory CD4-positive, alpha-beta T cell number
increased effector memory CD4-positive, alpha-beta T cell number
decreased CD4-positive, alpha beta T cell number
increased central memory CD8 positive, alpha-beta T cell number
increased effector memory CD8-positive, alpha-beta T cell number
decreased CD8-positive, naive alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
abnormal memory T cell number
decreased T cell number
decreased single-positive T cell number
increased single-positive T cell number
decreased lymphocyte cell number
increased macrophage cell number
abnormal marginal zone B cell morphology
abnormal spleen B cell follicle morphology
decreased spleen white pulp amount
abnormal B cell physiology
decreased IgD level
increased IgE level
decreased IgG level
increased IgM level
abnormal T cell physiology
abnormal CD4-positive, alpha-beta T cell physiology
abnormal CD8-positive, alpha-beta T cell physiology
Availability Mouse Genotype
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Stk4m1Btlr/Stk4m1Btlr
Stk4m2Btlr/Stk4m2Btlr
Stk4m3Btlr/Stk4m3Btlr
Stk4m4Btlr/Stk4m4Btlr
Stk4m5Btlr/Stk4m5Btlr
Stk4tm1.1Kina/Stk4tm1.1Kina
Stk4tm1.2Wtao/Stk4tm1.2Wtao
Stk4tm1Dlim/Stk4tm1Dlim
Stk4tm1.1Wtao/Stk4tm1.2Wtao
Tg(Lck-cre)#Zhu/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory