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mechanistic target of rapamycin kinase
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
decreased splenocyte apoptosis
decreased B cell proliferation
decreased T cell proliferation
decreased splenocyte proliferation
abnormal thymus cell ratio
decreased thymocyte number
abnormal B cell differentiation
decreased transitional stage T1 B cell number
abnormal T cell differentiation
decreased double-positive T cell number
decreased neutrophil cell number
decreased follicular B cell number
decreased marginal zone B cell number
decreased plasma cell number
decreased B cell number
abnormal T cell subpopulation ratio
decreased CD4-positive, alpha beta T cell number
increased CD4-positive, alpha beta T cell number
increased CD8-positive, alpha-beta T cell number
increased regulatory T cell number
decreased monocyte cell number
abnormal T cell morphology
small spleen
decreased splenocyte number
abnormal B cell physiology
decreased IgG level
decreased IgM level
abnormal T cell physiology
abnormal humoral immune response
decreased interferon-gamma secretion
decreased interleukin-17 secretion
decreased interleukin-2 secretion
decreased tumor necrosis factor secretion
Availability Mouse Genotype
Mtorchino/Mtorchino *
Mtortm1.1Lgm/Mtortm1.1Lgm *
Tg(Cd4-cre)1Cwi/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory