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Symbol
Name
ID
Trio
triple functional domain (PTPRF interacting)
MGI:1927230
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Intellectual disability
Poor speech
Attention deficit hyperactivity disorder
Aggressive behavior
Obsessive-compulsive behavior
Delayed speech and language development
Motor delay
Seizures
Disease(s) Associated with TRIO
autosomal dominant non-syndromic intellectual disability 44

Mouse Phenotypes
nervous system phenotype
increased neuron apoptosis
abnormal neuron differentiation
abnormal neuronal migration
abnormal cerebellar granule cell migration
abnormal cerebellum external granule cell layer morphology
abnormal rostral migratory stream morphology
decreased brain size
abnormal dentate gyrus morphology
abnormal olfactory bulb morphology
abnormal olfactory bulb mitral cell layer morphology
small olfactory bulb
abnormal Bergmann glial cell morphology
abnormal cerebellar granule layer morphology
abnormal cerebellar granule cell morphology
abnormal cerebellum lobule morphology
small cerebellum
Availability Mouse Genotype
Triotm1Mst/Triotm1Mst
Tg(GFAP-cre)#Mzhu/0
Triotm1Mzhu/Triotm1Mzhu  (conditional)
*
Tg(Nes-cre)1Kln/0
Triotm1Mzhu/Triotm1Mzhu  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory