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Symbol
Name
ID
Nckap1l
NCK associated protein 1 like
MGI:1926063
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Increased B cell count
Increased proportion of memory T cells
Hepatosplenomegaly
Disease(s) Associated with NCKAP1L
immunodeficiency 72

Mouse Phenotypes
impaired neutrophil chemotaxis
decreased T cell proliferation
impaired macrophage phagocytosis
impaired neutrophil phagocytosis
abnormal thymus lobule morphology
thymus hypoplasia
spleen hyperplasia
abnormal common myeloid progenitor cell morphology
abnormal lymphopoiesis
abnormal CD4-positive T cell differentiation
increased double-negative T cell number
decreased double-positive T cell number
extramedullary hematopoiesis
hypochromic microcytic anemia
abnormal erythroid progenitor cell morphology
decreased hematocrit
decreased mean corpuscular volume
acanthocytosis
dacryocytosis
poikilocytosis
schistocytosis
increased neutrophil cell number
decreased mature B cell number
decreased B cell number
decreased NK cell number
increased effector memory CD4-positive, alpha-beta T cell number
decreased CD4-positive, alpha beta T cell number
decreased central memory CD8 positive, alpha-beta T cell number
increased effector memory CD8-positive, alpha-beta T cell number
decreased CD8-positive, naive alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
increased CD8-positive, alpha-beta T cell number
decreased alpha-beta T cell number
increased alpha-beta T cell number
decreased mature gamma-delta T cell number
abnormal regulatory T cell number
decreased lymphocyte cell number
increased leukocyte cell number
reticulocytosis
increased erythrocyte osmotic fragility
Availability Mouse Genotype
Nckap1lm1Btlr/Nckap1lm1Btlr
Nckap1lm1Iri/Nckap1lm1Iri

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory