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Symbol
Name
ID
Kcnt1
potassium channel, subfamily T, member 1
MGI:1924627
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Postnatal microcephaly
Progressive microcephaly
Dysphagia
Central hypotonia
Spasticity
Delayed myelination
Hypoplasia of the corpus callosum
Thick corpus callosum
Cerebral atrophy
Cerebral cortical atrophy
Ventriculomegaly
Gliosis
Neuronal loss in central nervous system
EEG abnormality
Hypsarrhythmia
Abnormality of extrapyramidal motor function
Hyperreflexia
Clonus
Hemiparesis
Tetraplegia
Cognitive impairment
Absent speech
Dystonia
Inability to walk
Athetosis
Chorea
Choreoathetosis
Myoclonus
Stereotypy
Primitive reflex
Aggressive behavior
Irritability
Poor eye contact
Autism
Depressivity
Personality disorder
Psychosis
Epileptic encephalopathy
Developmental regression
Intellectual disability
Intellectual disability, profound
Global developmental delay
Hyporeflexia
Absence seizures
Epileptic spasms
Infantile spasms
Focal seizures
Generalized myoclonic seizures
Generalized tonic seizures
Multifocal seizures
Status epilepticus
Disease(s) Associated with KCNT1
autosomal dominant nocturnal frontal lobe epilepsy 5
Ohtahara syndrome

Mouse Phenotypes
impaired ability to fire action potentials
abnormal sensory neuron physiology
decreased channel response intensity
Availability Mouse Genotype
Kcnt1tm1.2Acsc/Kcnt1tm1.2Acsc
Kcnt1tm1.2Clin/Kcnt1tm1.2Clin

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory