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Symbol
Name
ID
Bicd2
BICD cargo adaptor 2
MGI:1924145
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Spasticity
Polymicrogyria
Hypoplasia of the corpus callosum
Cerebral cortical atrophy
Cerebellar hypoplasia
Ventriculomegaly
Hyperreflexia
Areflexia
Hyporeflexia
Toe walking
Waddling gait
Fasciculations
Motor delay
Disease(s) Associated with BICD2
spinal muscular atrophy with lower extremity predominance 2A
spinal muscular atrophy with lower extremity predominante 2B

Mouse Phenotypes
nervous system phenotype
abnormal neuronal migration
abnormal cerebellar granule cell migration
hydrocephaly
cerebral aqueductal stenosis
abnormal brain ependyma morphology
enlarged lateral ventricles
decreased corpus callosum size
decreased brain external capsule size
abnormal cerebellum white matter morphology
striatum atrophy
abnormal hippocampus layer morphology
abnormal hippocampus pyramidal cell layer
hippocampus atrophy
abnormal stratification in cerebral cortex
thin cerebral cortex
abnormal septum pellucidum morphology
forebrain atrophy
abnormal cerebellar layer morphology
abnormal cerebellar Purkinje cell layer
abnormal Purkinje cell dendrite morphology
abnormal cerebellar Golgi cell morphology
absent cerebellar granule layer
abnormal cerebellar molecular layer
small cerebellum
Availability Mouse Genotype
Bicd2tm1.1Hgrd/Bicd2tm1.1Hgrd
Bicd2tm1Hgrd/Bicd2tm1Hgrd
Tg(Nes-cre)1Atp/0  (conditional)
Bicd2tm1Hgrd/Bicd2tm1Hgrd
Tg(GFAP-cre)25Mes/0  (conditional)
Bicd2tm1Hgrd/Bicd2tm1Hgrd
Emx1tm1(cre)Krj/Emx1+  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory