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Symbol
Name
ID

Rspo2
R-spondin 2
MGI:1922667

Phenotype annotations related to craniofacial

Darker colors indicate more annotations

Human Phenotypes	Micrognathia	Microretrognathia	Bilateral cleft lip	Ankyloglossia	Cleft palate	Glossoptosis
Disease(s) Associated with RSPO2
tetraamelia syndrome 2

Mouse Phenotypes

short Meckel's cartilage

abnormal temporal bone squamous part morphology

abnormal tooth development

growth retardation of incisors

abnormal mandibular angle morphology

small mandibular condyloid process

absent mandibular coronoid process

small mandible

short mandible

abnormal maxilla morphology

abnormal maxillary shelf morphology

maxillary shelf hypoplasia

abnormal maxillary zygomatic process morphology

small maxilla

decreased palatine bone horizontal plate size

abnormal zygomatic bone morphology

delayed palatal shelf elevation

abnormal palatal shelf fusion at midline

palatal shelves fail to meet at midline

abnormal pharyngeal arch mesenchyme morphology

cleft upper lip

cleft secondary palate

cleft palate

decreased tongue size

Availability

Mouse Genotype

Rspo2^ftls/Rspo2^ftls

Rspo2^tm1Nuv/Rspo2^tm1Nuv

Rspo2^tm1Suda/Rspo2^tm1Suda

Rspo2^ftls/Rspo2⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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