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Symbol
Name
ID
Tdp1
tyrosyl-DNA phosphodiesterase 1
MGI:1920036
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Spastic dysarthria
Peripheral axonal neuropathy
Peripheral neuropathy
Sensorimotor neuropathy
Pain insensitivity
Distal sensory impairment
Impaired distal proprioception
Impaired vibration sensation in the lower limbs
Sensory neuropathy
Cerebral atrophy
Cerebellar atrophy
Cerebellar vermis atrophy
Global brain atrophy
Spinocerebellar tract degeneration
Ataxia
Dysarthria
Areflexia
Hyporeflexia
Steppage gait
Seizures
Disease(s) Associated with TDP1
spinocerebellar ataxia type 1 with axonal neuropathy

Mouse Phenotypes
small cerebellum
abnormal neuron physiology
Availability Mouse Genotype
Tdp1Gt(XD105)Byg/Tdp1Gt(XD105)Byg

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory