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Symbol
Name
ID
Cul4b
cullin 4B
MGI:1919834
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Polymicrogyria
Simplified gyral pattern
Cortical dysplasia
Abnormality of the cerebral white matter
Hypoplasia of the corpus callosum
Cerebellar vermis atrophy
Ventriculomegaly
EEG abnormality
Gait ataxia
Intellectual disability
Intellectual disability, moderate
Intellectual disability, severe
Neurological speech impairment
Absent speech
Broad-based gait
Hyperactivity
Tremor
Aggressive behavior
Mood swings
Delayed speech and language development
Motor delay
Seizures
Disease(s) Associated with CUL4B
syndromic X-linked intellectual disability Cabezas type

Mouse Phenotypes
increased susceptibility to pharmacologically induced seizures
abnormal dendrite morphology
abnormal dendritic spine morphology
decreased neuron number
Availability Mouse Genotype
Cul4btm1Swl/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory