Symbol
Name
ID

Abcg8
ATP binding cassette subfamily G member 8
MGI:1914720

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Hypercholesterolemia	Elevated circulating sitosterol concentration	Hyperapobetalipoproteinemia	Reduced haptoglobin level	Increased circulating lactate dehydrogenase concentration	Decreased resting energy expenditure
Disease(s) Associated with ABCG8	Hypercholesterolemia	Elevated circulating sitosterol concentration	Hyperapobetalipoproteinemia	Reduced haptoglobin level	Increased circulating lactate dehydrogenase concentration	Decreased resting energy expenditure
obesity
sitosterolemia

Mouse Phenotypes

increased circulating creatinine level

decreased circulating cholesterol level

increased circulating cholesterol level

increased circulating free fatty acids level

increased circulating phytosterol level

increased circulating triglyceride level

decreased circulating iron level

increased circulating potassium level

decreased circulating sodium level

increased circulating alanine transaminase level

increased circulating alkaline phosphatase level

increased circulating aspartate transaminase level

decreased circulating serum albumin level

abnormal cholesterol homeostasis

decreased cholesterol level

Availability

Mouse Genotype

Abcg8^{tm1b(KOMP)Wtsi}/Abcg8^{tm1b(KOMP)Wtsi}

Abcg8^tm1Elk/Abcg8^tm1Elk

Abcg8^tm1Elk/Abcg8⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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