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Symbol
Name
ID
Pnpla2
patatin-like phospholipase domain containing 2
MGI:1914103
Phenotype annotations related to homeostasis/metabolism
Darker colors indicate more annotations

Mouse Phenotypes
decreased fatty acid oxidation
increased susceptibility to diet-induced obesity
abnormal homeostasis
impaired adaptive thermogenesis
abnormal circulating glucose level
decreased circulating glucose level
abnormal circulating hormone level
abnormal circulating insulin level
decreased circulating insulin level
increased circulating leptin level
decreased circulating HDL cholesterol level
decreased circulating free fatty acid level
increased circulating free fatty acid level
decreased circulating triglyceride level
decreased circulating VLDL triglyceride level
increased circulating alanine transaminase level
cardiac edema
abnormal gas homeostasis
abnormal oxygen consumption
decreased oxygen consumption
abnormal respiratory quotient
increased respiratory quotient
abnormal glucose tolerance
improved glucose tolerance
increased cardiac muscle glycogen level
increased insulin sensitivity
abnormal lipid homeostasis
abnormal lipid level
increased fatty acid level
increased liver triglyceride level
decreased triglyceride level
increased triglyceride level
impaired lipolysis
abnormal metabolism
decreased basal metabolism
abnormal enzyme/coenzyme activity
Availability Mouse Genotype
Pnpla2tm1Rze/Pnpla2tm1Rze
Pnpla2tm1Rze/Pnpla2tm1Rze
Tg(Myh6-Pnpla2)94Biat/0
Tg(Ckm-Pnpla2)164Eek/0
Pnpla2tm1.1Hsul/Pnpla2tm1.1Hsul
Tg(Fabp4-cre)1Rev/0  (conditional)
Pnpla2tm1Eek/Pnpla2tm1Eek
Tg(Ckmm-cre)5Khn/0  (conditional)
Pnpla2tm1Eek/Pnpla2tm1Eek
Tg(Myog-cre)1Eno/0  (conditional)
Pnpla2tm1Gam/Pnpla2tm1Gam
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory