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Symbol Name ID |
Mtrr
5-methyltetrahydrofolate-homocysteine methyltransferase reductase MGI:1891037 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Hypercalcemia |
Hypermethioninemia |
Hypomethioninemia |
Hyperhomocystinemia |
Methylmalonic acidemia |
Elevated circulating creatinine concentration |
Hyperproteinemia |
Elevated circulating hepatic transaminase concentration |
Decreased methionine synthase activity |
Reduced cystathionine beta-synthase activity in cultured fibroblasts |
Diabetes mellitus |
Pleural effusion |
Abnormality of amino acid metabolism |
Abnormality of vitamin B12 metabolism |
Decreased circulating methylcobalamin concentration |
Hepatic steatosis |
Methylmalonic aciduria |
Homocystinuria |
Methioninuria |
Amyloidosis |
| Disease(s) Associated with MTRR | ||||||||||||||||||||||||
| homocystinuria | ||||||||||||||||||||||||
| homocystinuria-megaloblastic anemia cblE type | ||||||||||||||||||||||||
| multiple myeloma | ||||||||||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | abnormal amino acid level |
abnormal circulating homocysteine level |
increased circulating homocysteine level |
decreased circulating methionine level |
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| Availability | Mouse Genotype | ||||
| MtrrGt(XG334)Byg/MtrrGt(XG334)Byg | |||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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