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interleukin 21 receptor
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
decreased T cell proliferation
abnormal thymocyte activation
abnormal CD4-positive T cell differentiation
decreased basophil cell number
decreased eosinophil cell number
decreased granulocyte number
decreased CD4-positive, alpha beta T cell number
abnormal leukocyte physiology
impaired eosinophil recruitment
abnormal lymphocyte physiology
abnormal immunoglobulin level
decreased IgA level
decreased IgE level
increased IgE level
decreased IgG1 level
decreased IgG2a level
decreased IgG2b level
decreased IgG3 level
abnormal NK cell physiology
impaired natural killer cell mediated cytotoxicity
abnormal T cell physiology
abnormal T-helper 1 physiology
abnormal T-helper 2 physiology
abnormal CD8-positive, alpha-beta T cell physiology
decreased cytotoxic T cell cytolysis
abnormal T cell activation
abnormal memory T cell physiology
abnormal immune system morphology
abnormal immune system physiology
abnormal dendritic cell physiology
abnormal Langerhans cell physiology
abnormal plasmacytoid dendritic cell physiology
decreased susceptibility to type IV hypersensitivity reaction
decreased interferon-gamma secretion
increased interferon-gamma secretion
decreased interleukin-13 secretion
decreased interleukin-17 secretion
decreased interleukin-21 secretion
decreased interleukin-4 secretion
decreased susceptibility to autoimmune diabetes
increased susceptibility to experimental autoimmune encephalomyelitis
granulomatous inflammation
altered susceptibility to infection
Availability Mouse Genotype
Il21rtm1Kopf/Il21rtm1Kopf *

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory