|
Symbol Name ID |
Il21
interleukin 21 MGI:1890474 |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating IgA level |
Increased circulating IgE level |
Decreased circulating IgG level |
Chronic partially decreased circulating IgG1 |
Chronic (near) absent circulating IgG4 |
Decreased circulating total IgG |
Chronic decreased circulating total IgG |
Decreased circulating total IgM |
Decreased circulating antibody level |
Reduced isohemagglutinin level |
Decreased specific antibody response to vaccination |
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vaccine |
Partial absence of specific antibody response to unconjugated pneumococcus vaccine |
Complete or near-complete absence of specific antibody response to tetanus vaccine |
Decreased specific pneumococcal antibody level |
Impaired T cell function |
Purpura |
Hemolytic anemia |
Autoimmune hemolytic anemia |
Chronic neutropenia |
Neutropenia in presence of anti-neutropil antibodies |
Decreased proportion of class-switched memory B cells |
B lymphocytopenia |
Lymphopenia |
Pancytopenia |
Thrombocytopenia |
Autoimmune thrombocytopenia |
Lymphoma |
Lymphoproliferative disorder |
Splenomegaly |
| Disease(s) Associated with IL21 | ||||||||||||||||||||||||||||||
| common variable immunodeficiency |
| Mouse Phenotypes | abnormal class switch recombination |
abnormal T cell differentiation |
decreased germinal center B cell number |
decreased CD4-positive, alpha beta T cell number |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal gamma-delta T cell morphology |
abnormal spleen germinal center morphology |
decreased spleen germinal center number |
abnormal germinal center B cell physiology |
increased IgE level |
decreased IgG1 level |
abnormal CD4-positive, alpha-beta T cell physiology |
|
| Availability | Mouse Genotype | ||||||||||||
| Il21tm1Lex/Il21tm1Lex | |||||||||||||
| Il21tm1Llit/Il21tm1Llit | |||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support. |
last database update 06/28/2022 MGI 6.20 |
|
|
|
||
Analysis Tools