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Symbol
Name
ID
Il21
interleukin 21
MGI:1890474
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Decreased circulating IgA level
Increased circulating IgE level
Decreased circulating IgG level
Chronic partially decreased circulating IgG1
Chronic (near) absent circulating IgG4
Decreased circulating total IgG
Chronic decreased circulating total IgG
Decreased circulating total IgM
Decreased circulating antibody level
Reduced isohemagglutinin level
Decreased specific antibody response to vaccination
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vaccine
Partial absence of specific antibody response to unconjugated pneumococcus vaccine
Complete or near-complete absence of specific antibody response to tetanus vaccine
Decreased specific pneumococcal antibody level
Impaired T cell function
Purpura
Hemolytic anemia
Autoimmune hemolytic anemia
Chronic neutropenia
Neutropenia in presence of anti-neutropil antibodies
Decreased proportion of class-switched memory B cells
B lymphocytopenia
Lymphopenia
Pancytopenia
Thrombocytopenia
Autoimmune thrombocytopenia
Lymphoma
Lymphoproliferative disorder
Splenomegaly
Disease(s) Associated with IL21
common variable immunodeficiency

Mouse Phenotypes
abnormal class switch recombination
abnormal T cell differentiation
decreased germinal center B cell number
decreased CD4-positive, alpha beta T cell number
abnormal CD4-positive, alpha beta T cell morphology
abnormal gamma-delta T cell morphology
abnormal spleen germinal center morphology
decreased spleen germinal center number
abnormal germinal center B cell physiology
increased IgE level
decreased IgG1 level
abnormal CD4-positive, alpha-beta T cell physiology
Availability Mouse Genotype
Il21tm1Lex/Il21tm1Lex
Il21tm1Llit/Il21tm1Llit

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory