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Symbol
Name
ID
Dlg3
discs large MAGUK scaffold protein 3
MGI:1888986
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Postnatal microcephaly
Facial palsy
Drooling
Spasticity
Lower limb spasticity
Widened subarachnoid space
Cerebral atrophy
Cerebral cortical atrophy
EEG abnormality
Hypsarrhythmia
Ataxia
Progressive cerebellar ataxia
Poor fine motor coordination
Babinski sign
Intellectual disability
Intellectual disability, mild
Intellectual disability, moderate
Intellectual disability, profound
Intellectual disability, severe
Language impairment
Absent speech
Poor speech
Hyperreflexia
Hyperactivity
Attention deficit hyperactivity disorder
Stereotypy
Behavioral abnormality
Aggressive behavior
Poor eye contact
Autistic behavior
Autism
Anxiety
Bipolar affective disorder
Depressivity
Obsessive-compulsive behavior
Psychomotor retardation
Psychosis
Restlessness
Agitation
Short attention span
Epileptic encephalopathy
Delayed speech and language development
Global developmental delay
Motor delay
Delayed gross motor development
Seizures
Febrile seizures
Generalized-onset seizure
Absence seizure
Generalized myoclonic seizures
Generalized tonic-clonic seizures
Status epilepticus
Disease(s) Associated with DLG3
non-syndromic X-linked intellectual disability

Mouse Phenotypes
abnormal brain morphology
abnormal forebrain development
abnormal neocortex size
abnormal somatosensory cortex morphology
abnormal barrel cortex morphology
abnormal innervation
abnormal axon morphology
abnormal synapse morphology
decreased excitatory postsynaptic current amplitude
prolonged excitatory postsynaptic current decay time
abnormal long term potentiation
Availability Mouse Genotype
Dlg3Gt(P038A02)Wrst/Y
Dlg3tm1Grnt/Y

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/21/2020
MGI 6.14
The Jackson Laboratory