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Symbol
Name
ID

Fgf21
fibroblast growth factor 21
MGI:1861377

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

homeostasis/metabolism phenotype

impaired adaptive thermogenesis

abnormal blood homeostasis

decreased circulating glucose level

hypoglycemia

increased circulating glucose level

increased circulating insulin level

decreased circulating insulin-like growth factor I level

increased circulating leptin level

decreased circulating growth hormone level

increased circulating growth hormone level

decreased circulating ketone body level

increased circulating ketone body level

increased circulating cholesterol level

abnormal circulating free fatty acids level

decreased circulating free fatty acids level

increased circulating free fatty acids level

increased circulating triglyceride level

decreased body temperature

decreased oxygen consumption

increased oxygen consumption

abnormal glucose homeostasis

abnormal gluconeogenesis

impaired glucose tolerance

increased liver glycogen level

abnormal lipid homeostasis

abnormal lipid level

decreased fatty acids level

increased liver triglyceride level

enhanced lipolysis

impaired lipolysis

increased creatine kinase activity

decreased physiological sensitivity to xenobiotic

Availability

Mouse Genotype

Fgf21^tm1.1Djm/Fgf21^tm1.1Djm

Fgf21^tm1Emf/Fgf21^tm1Emf

Fgf21^tm1Fdl/Fgf21^tm1Fdl

Fgf21^tm1Lex/Fgf21^tm1Lex

Fgf21^tm1Nit/Fgf21^tm1Nit

*

Tg(Apoe-Fgf21)1Sakl/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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