Symbol
Name
ID

Irf6
interferon regulatory factor 6
MGI:1859211

Phenotype annotations related to growth/size/body

Darker colors indicate more annotations

Human Phenotypes	Short neck	Inguinal hernia	Omphalocele	Inferiorly positioned umbilicus	Intrauterine growth retardation
Disease(s) Associated with IRF6
popliteal pterygium syndrome

Mouse Phenotypes

abnormal tooth morphology

taurodontia

abnormal incisor morphology

abnormal incisor color

abnormal molar morphology

abnormal molar crown morphology

abnormal molar cusp morphology

abnormal molar root morphology

decreased molar number

abnormal tooth development

abnormal enamel development

abnormal ameloblast morphology

abnormal enamel mineralization

abnormal enamel morphology

abnormal enamel rod pattern

reduced enamel thickness

supernumerary teeth

abnormal Hertwig epithelial root sheath morphology

abnormal palatine bone horizontal plate morphology

abnormal palate development

failure of palatal shelf elevation

palatal shelf fusion with tongue or mandible

abnormal mouth morphology

abnormal oral cavity morphology

cleft secondary palate

cleft palate

glossopalatal ankylosis

round snout

short snout

absent outer ear

Availability

Mouse Genotype

Irf6^clft1/Irf6^clft1

Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex}

Irf6^tm1Mjd/Irf6^tm1Mjd

Irf6^tm1Mjd/Irf6⁺

Irf6^tm1Bcsl/Irf6^tm1Bcsl
Pitx2^tm4(cre)Jfm/Pitx2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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