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Symbol
Name
ID
Pla2g6
phospholipase A2, group VI
MGI:1859152
Phenotype annotations related to behavior/neurological
Darker colors indicate more annotations
Human Phenotypes
Drooling
Feeding difficulties
Depression
Emotional lability
Apathy
Reduced social reciprocity
Personality changes
Aggressive behavior
Hyperactivity
Impulsivity
Agitation
Restless legs
Disease(s) Associated with PLA2G6
dystonia 12
neurodegeneration with brain iron accumulation 2a
neurodegeneration with brain iron accumulation 2b
Parkinson's disease
Parkinson's disease 14

Mouse Phenotypes
increased exploration in new environment
abnormal motor capabilities/coordination/movement
tremors
abnormal motor coordination/balance
ataxia
impaired coordination
impaired limb coordination
decreased grip strength
abnormal locomotor coordination
abnormal gait
decreased vertical activity
decreased locomotor activity
bradykinesia
hindlimb paralysis
Availability Mouse Genotype
Pla2g6m1J/Pla2g6m1J
Pla2g6m1Sein/Pla2g6m1Sein
Pla2g6tm1.1Hlw/Pla2g6tm1.1Hlw
Pla2g6tm1Tsu/Pla2g6tm1Tsu
Pla2g6tm1Turk/Pla2g6tm1Turk

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory