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Symbol
Name
ID
Atoh7
atonal bHLH transcription factor 7
MGI:1355553
Phenotype annotations related to vision/eye
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Hemorrhage of the eye
Hyphema
Posterior synechiae of the anterior chamber
Shallow anterior chamber
Microcornea
Corneal opacity
Cataract
Developmental cataract
Leukocoria
Persistent pupillary membrane
Iris coloboma
Buphthalmos
Macular hypoplasia
Retinal nonattachment
Tractional retinal detachment
Retinal fold
Remnants of the hyaloid vascular system
Glial remnants anterior to the optic disc
Hyaloid vascular remnant and retrolental mass
Uveitis
Microphthalmia
Phthisis bulbi
Strabismus
Esotropia
Pendular nystagmus
Reduced visual acuity
Amblyopia
Blindness
Ultra-low vision with no light perception
Glaucoma
Angle closure glaucoma
Epiphora
Disease(s) Associated with ATOH7
persistent hyperplastic primary vitreous

Mouse Phenotypes
vision/eye phenotype
abnormal retina vasculature morphology
increased retina apoptosis
abnormal Muller cell morphology
decreased retina ganglion cell number
absent retina ganglion cell
decreased retina rod cell number
increased amacrine cell number
increased retina photoreceptor cell number
increased retina cone cell number
abnormal amacrine cell morphology
abnormal retina bipolar cell morphology
abnormal retina cone bipolar cell morphology
abnormal retina rod bipolar cell morphology
abnormal retina ganglion cell morphology
abnormal retina cone cell morphology
abnormal optic nerve morphology
decreased optic chiasm size
absent optic nerve
optic nerve hypoplasia
abnormal eye development
abnormal optic vesicle formation
abnormal retina morphology
abnormal retina ganglion layer morphology
absent retina ganglion layer
thin retina inner nuclear layer
thin retina inner plexiform layer
abnormal retina nerve fiber layer morphology
thin retina outer nuclear layer
thin retina outer plexiform layer
decreased total retina thickness
abnormal eye electrophysiology
abnormal rod electrophysiology
Availability Mouse Genotype
Atoh7tm1.1(Ascl1)Nlbr/Atoh7tm1.1(Ascl1)Nlbr
Atoh7tm1Gan/Atoh7tm1Gan
Atoh7tm1Gla/Atoh7tm1Gla
Atoh7tm2Gan/Atoh7tm2Gan
Atoh7tm3(cre)Gan/Atoh7tm3(cre)Gan *
Atoh7tm1(Neurod1)Whk/Atoh7tm2(Neurod4)Whk *
Atoh7tm1Gan/Atoh7tm1(Neurod1)Whk
Atoh7tm1Gan/Atoh7tm2(Neurod4)Whk
Atoh7tm1Gan/Atoh7tm2Gan

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory