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Symbol
Name
ID
Prkn
parkin RBR E3 ubiquitin protein ligase
MGI:1355296
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Substantia nigra gliosis
Bradykinesia
Parkinsonism
Rigidity
Hyperreflexia
Dystonia
Gait disturbance
Tremor
Postural instability
Disease(s) Associated with PRKN
Parkinson's disease 2

Mouse Phenotypes
nervous system phenotype
increased neuron apoptosis
decreased noradrenaline level
abnormal substantia nigra pars compacta morphology
decreased substantia nigra size
abnormal locus ceruleus morphology
hippocampal neuron degeneration
brain vacuoles
tau protein deposits
abnormal CNS glial cell morphology
abnormal neuron morphology
decreased dopaminergic neuron number
loss of dopaminergic neurons
neuron degeneration
abnormal nervous system electrophysiology
abnormal synaptic transmission
Availability Mouse Genotype
Prkntm1Ccs/Prkntm1Ccs *
Prkntm1Roo/Prkntm1Roo *
Prkntm1Rpa/Prkntm1Rpa *
Prkntm1Shn/Prkntm1Shn
Prkntm1Tmd/Prkntm1Tmd
Prkntm1Ykt/Prkntm1Ykt
Prkntm2Tmd/Prkntm2Tmd  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory