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phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
impaired macrophage chemotaxis
impaired neutrophil chemotaxis
decreased T cell proliferation
thymus hypoplasia
decreased thymocyte number
abnormal NK cell differentiation
abnormal T cell differentiation
increased eosinophil cell number
decreased neutrophil cell number
increased neutrophil cell number
decreased CD4-positive, alpha beta T cell number
decreased CD8-positive, alpha-beta T cell number
decreased macrophage cell number
increased monocyte cell number
increased leukocyte cell number
abnormal leukocyte physiology
abnormal neutrophil physiology
impaired neutrophil recruitment
decreased immunoglobulin level
abnormal T cell physiology
abnormal T-helper 2 physiology
abnormal CD8-positive, alpha-beta T cell physiology
decreased cytotoxic T cell cytolysis
abnormal T cell activation
abnormal macrophage physiology
abnormal immune cell physiology
decreased interferon-gamma secretion
increased interleukin-1 beta secretion
decreased interleukin-2 secretion
increased interleukin-6 secretion
increased tumor necrosis factor secretion
decreased susceptibility to induced arthritis
abnormal inflammatory response
decreased inflammatory response
abnormal response to infection
increased susceptibility to bacterial infection
increased susceptibility to viral infection
Availability Mouse Genotype
Pik3cgtm1Dwu/Pik3cgtm1Dwu *

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory