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Symbol
Name
ID
Dtx1
deltex 1, E3 ubiquitin ligase
MGI:1352744
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
decreased thymocyte apoptosis
increased B cell proliferation
decreased T cell proliferation
increased T cell proliferation
abnormal thymocyte activation
decreased marginal zone B cell number
abnormal lymphocyte morphology
spleen hyperplasia
abnormal lymphocyte physiology
abnormal T cell activation
abnormal regulatory T cell physiology
increased interferon-gamma secretion
decreased interleukin-2 secretion
increased interleukin-2 secretion
increased interleukin-4 secretion
abnormal T cell anergy
increased autoantibody level
increased anti-double stranded DNA antibody level
increased anti-histone antibody level
liver inflammation
glomerulonephritis
lung inflammation
Availability Mouse Genotype
Dtx1tm1.2Mzl/Dtx1tm1.2Mzl
Dtx1tm1Mjb/Dtx1tm1Mjb *
Tg(Cd4-Dtx1)1Mzl/?
Dtx1tm1.1Mzl/Dtx1tm1.1Mzl
Tg(Cd4-cre)1Cwi/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory