Symbol
Name
ID

Esr1
estrogen receptor 1 (alpha)
MGI:1352467

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Abnormality of chromosome stability	Chromosome breakage	Increased LDL cholesterol concentration	Hypercholesterolemia	Hypertriglyceridemia	Glucose intolerance	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance	Insulin resistance
Disease(s) Associated with ESR1	Abnormality of chromosome stability	Chromosome breakage	Increased LDL cholesterol concentration	Hypercholesterolemia	Hypertriglyceridemia	Glucose intolerance	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance	Insulin resistance
coronary artery disease
systemic scleroderma
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

abnormal response of heart to induced stress

abnormal vascular wound healing

increased circulating glucose level

decreased circulating testosterone level

increased circulating testosterone level

decreased circulating estradiol level

increased circulating estradiol level

decreased circulating luteinizing hormone level

decreased circulating prolactin level

increased circulating follicle stimulating hormone level

increased circulating luteinizing hormone level

decreased circulating insulin-like growth factor I level

increased circulating leptin level

decreased circulating osteocalcin level

decreased circulating progesterone level

increased circulating HDL cholesterol level

increased circulating cholesterol level

decreased energy expenditure

impaired glucose tolerance

insulin resistance

abnormal luteinizing hormone level

increased luteinizing hormone level

increased urine protein level

albuminuria

abnormal response/metabolism to endogenous compounds

abnormal physiological response to xenobiotic

decreased physiological sensitivity to xenobiotic

Availability

Mouse Genotype

Esr1^tm1.1Gust/Esr1^tm1.1Gust

Esr1^tm1.1Ics/Esr1^tm1.1Ics

Esr1^tm1.1Mma/Esr1^tm1.1Mma

Esr1^tm1.1Ohl/Esr1^tm1.1Ohl

Esr1^tm1.1Pws/Esr1^tm1.1Pws

Esr1^tm1Arnal/Esr1^tm1Arnal

Esr1^tm1Geog/Esr1^tm1Geog

Esr1^tm1Ksk/Esr1^tm1Ksk

Esr1^tm2Ksk/Esr1^tm2Ksk

Esr1^tm3.1Ksk/Esr1^tm3.1Ksk

Esr1^tm4.2Ksk/Esr1^tm4.2Ksk

Esr1^tm1.1Lja/Esr1⁺

Esr1^tm1.1Lja/Esr1^tm1.1Mma

Esr1^tm1.2Awo/Esr1^tm1.2Awo
Tg(Cga-cre)1Awo/0 (conditional)

Esr1^tm1.2Awo/Esr1^tm1.2Awo
Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ (conditional)

Esr1^tm1.2Mma/Esr1^tm1.2Mma
Tg(Cyp17a1-icre)AJako/0 (conditional)

Esr1^tm1Gsc/Esr1^tm1Gsc
Tg(Camk2a-cre)2Gsc/0 (conditional)

Esr1^tm1Syeh/Esr1^tm1Syeh
Tmem163^{Tg(ACTB-cre)2Mrt}/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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