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Symbol
Name
ID
Nbn
nibrin
MGI:1351625
Phenotype annotations related to neoplasm
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Acute leukemia
Acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemias
Lymphoma
B-cell lymphoma
T-cell lymphoma
Breast carcinoma
Prostate cancer
Dysgerminoma
Ovarian papillary adenocarcinoma
Rhabdomyosarcoma
Glioma
Medulloblastoma
Neoplasm
Disease(s) Associated with NBN
acute lymphoblastic leukemia
breast cancer
Nijmegen breakage syndrome
ovarian cancer
prostate cancer

Mouse Phenotypes
neoplasm
increased mammary adenocarcinoma incidence
increased prostate intraepithelial neoplasia incidence
increased Leydig cell tumor incidence
increased T cell derived lymphoma incidence
increased thyroid adenoma incidence
increased liver adenocarcinoma incidence
increased liver adenoma incidence
increased T cell acute lymphoblastic leukemia incidence
increased lymphoma incidence
increased B cell derived lymphoma incidence
increased lung adenocarcinoma incidence
increased incidence of tumors by ionizing radiation induction
increased gonad tumor incidence
increased tumor incidence
decreased tumor latency
Availability Mouse Genotype
Nbnem3Jpt/Nbnem3Jpt *
Nbnem4Jpt/Nbnem4Jpt *
Nbntm1Jpt/Nbntm1Jpt *
Nbntm1Xu/Nbntm1Xu
Nbntm1Nus/Nbn+ *
Nbntm1Zqw/Nbn+
Nbnem7Jpt/Nbntm2Zqw
Tg(VAV1-cre)1Graf/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory