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Symbol
Name
ID
Nbn
nibrin
MGI:1351625
Phenotype annotations related to neoplasm
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemias
Lymphoma
Rhabdomyosarcoma
Glioma
Medulloblastoma
Disease(s) Associated with NBN
acute lymphocytic leukemia
Nijmegen breakage syndrome

Mouse Phenotypes
neoplasm
increased mammary adenocarcinoma incidence
increased prostate intraepithelial neoplasia incidence
increased Leydig cell tumor incidence
increased T cell derived lymphoma incidence
increased thyroid adenoma incidence
increased liver adenocarcinoma incidence
increased liver adenoma incidence
increased lymphoma incidence
increased B cell derived lymphoma incidence
increased lung adenocarcinoma incidence
increased incidence of tumors by ionizing radiation induction
increased gonad tumor incidence
increased tumor incidence
decreased tumor latency
Availability Mouse Genotype
Nbntm1Jpt/Nbntm1Jpt *
Nbntm1Xu/Nbntm1Xu
Nbntm1Nus/Nbn+ *
Nbntm1Zqw/Nbn+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory