Symbol Name ID |
Nbn
nibrin MGI:1351625 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Acute leukemia |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Lymphoma |
B-cell lymphoma |
T-cell lymphoma |
Breast carcinoma |
Prostate cancer |
Dysgerminoma |
Ovarian papillary adenocarcinoma |
Rhabdomyosarcoma |
Glioma |
Medulloblastoma |
Neoplasm |
Disease(s) Associated with NBN | ||||||||||||||
acute lymphoblastic leukemia | ||||||||||||||
breast cancer | ||||||||||||||
Nijmegen breakage syndrome | ||||||||||||||
ovarian cancer | ||||||||||||||
prostate cancer |
Mouse Phenotypes | neoplasm |
increased mammary adenocarcinoma incidence |
increased prostate intraepithelial neoplasia incidence |
increased Leydig cell tumor incidence |
increased T cell derived lymphoma incidence |
increased thyroid adenoma incidence |
increased liver adenocarcinoma incidence |
increased liver adenoma incidence |
increased T cell acute lymphoblastic leukemia incidence |
increased lymphoma incidence |
increased B cell derived lymphoma incidence |
increased lung adenocarcinoma incidence |
increased incidence of tumors by ionizing radiation induction |
increased gonad tumor incidence |
increased tumor incidence |
decreased tumor latency |
|
Availability | Mouse Genotype | ||||||||||||||||
Nbnem3Jpt/Nbnem3Jpt | * | ||||||||||||||||
Nbnem4Jpt/Nbnem4Jpt | * | ||||||||||||||||
Nbntm1Jpt/Nbntm1Jpt | * | ||||||||||||||||
Nbntm1Xu/Nbntm1Xu | |||||||||||||||||
Nbntm1Nus/Nbn+ | * | ||||||||||||||||
Nbntm1Zqw/Nbn+ | |||||||||||||||||
Nbnem7Jpt/Nbntm2Zqw Tg(VAV1-cre)1Graf/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/12/2024 MGI 6.23 |
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