Symbol
Name
ID

Foxa2
forkhead box A2
MGI:1347476

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Type II diabetes mellitus	Insulin resistance
Disease(s) Associated with FOXA2	Type II diabetes mellitus	Insulin resistance
type 2 diabetes mellitus

Mouse Phenotypes

abnormal insulin secretion

decreased circulating glucose level

hypoglycemia

decreased circulating glucagon level

decreased circulating insulin level

increased circulating insulin level

decreased circulating free fatty acids level

increased circulating free fatty acids level

increased circulating triglyceride level

cyanosis

increased carbon dioxide production

increased oxygen consumption

abnormal glucose homeostasis

improved glucose tolerance

increased glycogen level

increased insulin sensitivity

increased liver triglyceride level

abnormal metabolism

increased basal metabolism

increased susceptibility to injury

Availability

Mouse Genotype

Foxa2^tm1.1Khk/Foxa2⁺

Foxa2^tm1Dnl/Foxa2⁺

Foxa2^tm1.1Stf/Foxa2^tm1.1Stf
Tg(Nes-cre)1Kln/0 (conditional)

Foxa2^tm1.1Stf/Foxa2^tm1.1Stf (conditional)

Foxa2^tm1Khk/Foxa2^tm1Khk (conditional)

Foxa2^tm1Khk/Foxa2^tm1Khk
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0 (conditional)

Foxa2^tm1Khk/Foxa2^tm1Khk
Tg(Foxa3-cre)1Khk/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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