Symbol
Name
ID

Fto
FTO alpha-ketoglutarate dependent dioxygenase
MGI:1347093

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Increased LDL cholesterol concentration	Hypercholesterolemia	Hypertriglyceridemia	Decreased resting energy expenditure	Glucose intolerance	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance	Insulin resistance	Calcification of the aorta
Disease(s) Associated with FTO	Increased LDL cholesterol concentration	Hypercholesterolemia	Hypertriglyceridemia	Decreased resting energy expenditure	Glucose intolerance	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance	Insulin resistance	Calcification of the aorta
aortic valve disease 2
coronary artery disease
obesity
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

decreased susceptibility to diet-induced obesity

increased susceptibility to diet-induced obesity

increased circulating glucose level

abnormal circulating hormone level

increased circulating adrenaline level

increased circulating glucagon level

decreased circulating insulin level

decreased circulating insulin-like growth factor I level

decreased circulating leptin level

increased circulating leptin level

increased circulating HDL cholesterol level

decreased circulating LDL cholesterol level

increased circulating cholesterol level

increased circulating triglyceride level

decreased circulating iron level

decreased circulating alanine transaminase level

decreased circulating aspartate transaminase level

abnormal urine catecholamine level

increased energy expenditure

decreased lactate dehydrogenase level

abnormal carbon dioxide production

decreased carbon dioxide production

increased carbon dioxide production

abnormal oxygen consumption

increased oxygen consumption

decreased respiratory quotient

increased respiratory quotient

improved glucose tolerance

abnormal metabolism

increased basal metabolism

Availability

Mouse Genotype

Fto^I367F/Fto^I367F

Fto^tm1.2Pzg/Fto^tm1.2Pzg

Fto^tm1.2Rdc/Fto^tm1.2Rdc

Fto^tm1.3Pzg/Fto^tm1.3Pzg

Fto^{tm1a(EUCOMM)Wtsi}/Fto^{tm1a(EUCOMM)Wtsi}

Fto^tm1Urt/Fto^tm1Urt

Fto^I367F/Fto⁺

Fto^tm1Urt/Fto⁺

Fto^tm1.1Pzg/Fto^tm1.1Pzg
Tg(Nes-cre)1Kln/0 (conditional)

Fto^tm1.1Rdc/Fto^tm1.1Rdc (conditional)

Fto^tm1.1Rdc/Fto^tm1.1Rdc
Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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