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Symbol
Name
ID
Fto
fat mass and obesity associated
MGI:1347093
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
homeostasis/metabolism phenotype
decreased susceptibility to diet-induced obesity
increased susceptibility to diet-induced obesity
increased circulating glucose level
abnormal circulating hormone level
increased circulating adrenaline level
increased circulating glucagon level
decreased circulating insulin level
increased circulating insulin level
decreased circulating insulin-like growth factor I level
decreased circulating leptin level
increased circulating leptin level
abnormal circulating lipid level
increased circulating HDL cholesterol level
decreased circulating LDL cholesterol level
increased circulating cholesterol level
increased circulating free fatty acid level
increased circulating triglyceride level
decreased circulating iron level
decreased circulating alanine transaminase level
decreased circulating aspartate transaminase level
abnormal urine catecholamine level
increased energy expenditure
decreased lactate dehydrogenase level
abnormal carbon dioxide production
decreased carbon dioxide production
increased carbon dioxide production
abnormal oxygen consumption
increased oxygen consumption
decreased respiratory quotient
increased respiratory quotient
impaired glucose tolerance
improved glucose tolerance
abnormal hormone level
decreased adiponectin level
abnormal metabolism
increased basal metabolism
Availability Mouse Genotype
FtoI367F/FtoI367F
Ftotm1.2Pzg/Ftotm1.2Pzg
Ftotm1.2Rdc/Ftotm1.2Rdc *
Ftotm1.3Pzg/Ftotm1.3Pzg
Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Ftotm1Urt/Ftotm1Urt
Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
FtoI367F/Fto+
Ftotm1Urt/Fto+
Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Ftotm1.1Pzg/Ftotm1.1Pzg
Tg(Nes-cre)1Kln/0  (conditional)
Ftotm1.1Rdc/Ftotm1.1Rdc  (conditional) *
Ftotm1.1Rdc/Ftotm1.1Rdc
Ndor1Tg(UBC-cre/ERT2)1Ejb/0  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory