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Symbol
Name
ID 		Mapk1
mitogen-activated protein kinase 1
MGI:1346858
Phenotype annotations related to craniofacial
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Low posterior hairline
Plagiocephaly
Micrognathia
Microcephaly
Prominent metopic ridge
Coarse facial features
Pointed chin
High forehead
Narrow forehead
Long philtrum
U-Shaped upper lip vermilion
High palate
Wide mouth
Microdontia
Widely spaced teeth
Anteverted nares
Wide nasal bridge
Broad eyebrow
Highly arched eyebrow
Almond-shaped palpebral fissure
Downslanted palpebral fissures
Epicanthus
Disease(s) Associated with MAPK1
Noonan syndrome 13

Mouse Phenotypes
craniofacial phenotype
abnormal Meckel's cartilage morphology
small Meckel's cartilage
abnormal mandible morphology
abnormal mandibular angle morphology
small mandibular condyloid process
abnormal mandibular coronoid process morphology
small mandible
mandible hypoplasia
maxilla hypoplasia
short maxilla
micrognathia
failure of palatal shelf elevation
cleft palate
complete cleft palate
abnormal tongue morphology
abnormal tongue muscle morphology
abnormal extrinsic tongue muscle morphology
abnormal tongue position
decreased tongue size
Availability Mouse Genotype
Mapk1tm1Gela/Mapk1tm1Gela
H2az2Tg(Wnt1-cre)11Rth/0  (conditional)
Mapk1tm1Gela/Mapk1tm1Gela
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Mapk1tm1Gela/Mapk1tm1Gela
Osr2tm2(cre)Jian/Osr2+  (conditional)		 *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory