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Symbol
Name
ID

Sh3bp2
SH3-domain binding protein 2
MGI:1346349

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes	Jaw swelling
Disease(s) Associated with SH3BP2	Jaw swelling
cherubism

Mouse Phenotypes

abnormal osteoclast differentiation

abnormal craniofacial bone morphology

abnormal neurocranium morphology

abnormal jaw morphology

alveolar process atrophy

increased osteoclast cell number

abnormal osteoclast physiology

joint inflammation

osteomyelitis

short tibia

abnormal skeleton morphology

abnormal long bone morphology

abnormal bone structure

decreased bone mineral density

increased bone mineral density

decreased trabecular bone volume

increased trabecular bone volume

abnormal compact bone morphology

increased compact bone thickness

increased osteoblast cell number

decreased bone trabecula number

increased bone trabecula number

increased trabecular bone thickness

increased bone mass

abnormal skeleton physiology

abnormal bone ossification

Availability

Mouse Genotype

Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics

Sh3bp2^{tm1b(KOMP)Wtsi}/Sh3bp2^{tm1b(KOMP)Wtsi}

Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro

Sh3bp2^{tm1c(KOMP)Wtsi}/Sh3bp2^{tm1c(KOMP)Wtsi}

Sh3bp2^tm1Bjro/Sh3bp2⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23