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Symbol
Name
ID
Tlr2
toll-like receptor 2
MGI:1346060
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Abnormality of the immune system
Disease(s) Associated with TLR2
leprosy

Mouse Phenotypes
immune system phenotype
increased B cell apoptosis
abnormal leukocyte migration
abnormal cellular extravasation
decreased splenocyte proliferation
increased susceptibility to induced colitis
insulitis
decreased basophil cell number
increased T cell number
decreased immunoglobulin level
abnormal macrophage physiology
decreased macrophage cytokine production
decreased macrophage nitric oxide production
decreased microglial cell activation
abnormal osteoclast physiology
decreased circulating interleukin-1 beta level
decreased circulating tumor necrosis factor level
abnormal chemokine level
abnormal interleukin level
abnormal tumor necrosis factor level
abnormal dendritic cell physiology
abnormal cytokine secretion
abnormal interleukin secretion
decreased interleukin-1 beta secretion
decreased interleukin-1 secretion
decreased interleukin-10 secretion
decreased interleukin-12 secretion
decreased interleukin-12b secretion
decreased interleukin-6 secretion
decreased tumor necrosis factor secretion
decreased inflammatory response
abnormal innate immunity
decreased susceptibility to bacterial infection induced morbidity/mortality
increased susceptibility to bacterial infection
increased susceptibility to bacterial infection induced morbidity/mortality
decreased susceptibility to viral infection induced morbidity/mortality
decreased susceptibility to parasitic infection
decreased susceptibility to viral infection
Availability Mouse Genotype
Tlr2lngd/Tlr2lngd
Tlr2tm1.1(KOMP)Vlcg/Tlr2tm1.1(KOMP)Vlcg
Tlr2tm1Aki/Tlr2tm1Aki *
Tlr2tm1Kir/Tlr2tm1Kir

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory