Symbol
Name
ID

Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
MGI:1342774

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Depression	Emotional lability	Atypical behavior	Apathy	Reduced social reciprocity	Personality changes	Impulsivity	Agitation	Restless legs	Fatigue	Pain
Disease(s) Associated with PPARGC1A	Depression	Emotional lability	Atypical behavior	Apathy	Reduced social reciprocity	Personality changes	Impulsivity	Agitation	Restless legs	Fatigue	Pain
amyotrophic lateral sclerosis
Huntington's disease
Parkinson's disease

Mouse Phenotypes

behavior/neurological phenotype

abnormal behavioral response to amphetamine

decreased food intake

abnormal depression-related behavior

anhedonia

increased thigmotaxis

increased startle reflex

limb grasping

dystonia

impaired coordination

decreased grip strength

abnormal locomotor behavior

decreased locomotor activity

hyperactivity

bradykinesia

fatigue

myoclonus

Availability

Mouse Genotype

Ppargc1a^tm1Brsp/Ppargc1a^tm1Brsp

Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk

Ppargc1a^em1(IMPC)Bay/Ppargc1a⁺

Ppargc1a^tm1Aztc/Ppargc1a⁺

Tg(Ckm-Ppargc1a)31Brsp/0

Ppargc1a^tm2.1Brsp/Ppargc1a^tm2.1Brsp (conditional)

Ppargc1a^tm1Brsp/Ppargc1a^tm2Brsp
Tg(Myog-cre)1Eno/0 (conditional)

Ppargc1a^tm2Brsp/Ppargc1a⁺
Tg(Myog-cre)1Eno/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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