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Symbol
Name
ID
Mmp13
matrix metallopeptidase 13
MGI:1340026
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Coxa vara
Femoral bowing
Tibial bowing
Radial bowing
Ulnar bowing
Metaphyseal cupping
Flared metaphysis
Genu varum
Limited elbow extension
Rhizomelia
Flattened epiphysis
Small epiphyses
Flared iliac wings
Flared, irregular rib ends
Irregular sclerotic endplates
Pear-shaped vertebrae
Platyspondyly
Osteoarthritis
Spondyloepimetaphyseal dysplasia
Delayed skeletal maturation
Disease(s) Associated with MMP13
spondyloepimetaphyseal dysplasia, Missouri type

Mouse Phenotypes
abnormal bone healing
short femur
abnormal long bone hypertrophic chondrocyte zone
increased width of hypertrophic chondrocyte zone
increased long bone epiphyseal plate size
abnormal trabecular bone morphology
increased trabecular bone mass
abnormal cartilage development
delayed bone ossification
Availability Mouse Genotype
Mmp13tm1.1Werb/Mmp13tm1.1Werb
Mmp13tm1Jdar/Mmp13tm1Jdar
Mmp13tm1Smk/Mmp13tm1Smk
Mmp13tm1Werb/Mmp13tm1Werb
Tg(Col1a1-cre)1Kry/0  (conditional)
Mmp13tm1Werb/Mmp13tm1Werb
Tg(Col2a1-cre)1Rsjo/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory