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SMAD family member 6
Phenotype annotations related to cardiovascular system
Darker colors indicate more annotations
Human Phenotypes
Bicuspid aortic valve
Calcification of the aorta
Coarctation of aorta
Disease(s) Associated with SMAD6
aortic valve disease 2

Mouse Phenotypes
abnormal aorta morphology
abnormal cardiac epithelial to mesenchymal transition
abnormal truncus arteriosus septation
abnormal heart morphology
abnormal coronary vessel morphology
double outlet right ventricle
overriding aortic valve
d-loop transposition of the great arteries
enlarged mitral valve
tricuspid valve atresia
abnormal endocardium morphology
perimembraneous ventricular septal defect
muscular ventricular septal defect
abnormal heart valve morphology
enlarged pulmonary valve
heart valve hyperplasia
abnormal cardiovascular system physiology
poor circulation
abnormal blood vessel physiology
decreased vasodilation
increased systemic arterial blood pressure
Availability Mouse Genotype

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory