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Symbol
Name
ID
Trp63
transformation related protein 63
MGI:1330810
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Abnormality of dental enamel
Malar flattening
Micrognathia
Hypoplasia of the maxilla
Aplasia/Hypoplasia involving the metacarpal bones
Aplasia/Hypoplasia of the phalanges of the hand
Triphalangeal thumb
Clinodactyly of the 5th finger
Aplasia/Hypoplasia of the phalanges of the toes
Toe syndactyly
2-3 toe syndactyly
Syndactyly
Finger syndactyly
Aplasia/Hypoplasia of metatarsal bones
Ectrodactyly
Split foot
Split hand
Disease(s) Associated with TP63
ADULT syndrome
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3
Rapp-Hodgkin syndrome
split hand-foot malformation 4

Mouse Phenotypes
absent tooth placode
absent teeth
small mandible
small maxilla
absent carpal bone
abnormal phalanx morphology
abnormal humerus morphology
absent radius
absent ulna
abnormal limb bone morphology
abnormal pelvic girdle bone morphology
absent pubic symphysis
intervertebral disk degeneration
kyphosis
Availability Mouse Genotype
Trp63tm1.1Elrf/Trp63tm1.1Elrf
Trp63tm1Brd/Trp63tm1Brd
Trp63tm1Fmc/Trp63tm1Fmc
Trp63tm2Brd/Trp63tm2Brd
Trp63tm1Aam/Trp63+
Trp63tm1Fmc/Trp63+
Tg(KRT5-cre/PGR)1Der/0
Trp63tm2Brd/Trp63tm3.1Brd  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory