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Symbol
Name
ID
Trp63
transformation related protein 63
MGI:1330810
Phenotype annotations related to limbs/digits/tail
Darker colors indicate more annotations
Human Phenotypes
Clinodactyly of the 5th finger
Aplasia/Hypoplasia of the phalanges of the hand
Triphalangeal thumb
Aplasia/Hypoplasia of the phalanges of the toes
Toe syndactyly
2-3 toe syndactyly
Syndactyly
Finger syndactyly
Aplasia/Hypoplasia of metatarsal bones
Aplasia/Hypoplasia involving the metacarpal bones
Ectrodactyly
Split foot
Split hand
Disease(s) Associated with TP63
ADULT syndrome
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3
Rapp-Hodgkin syndrome
split hand-foot malformation 4

Mouse Phenotypes
abnormal apical ectodermal ridge morphology
absent apical ectodermal ridge
abnormal limb bud morphology
small limb buds
small tail bud
abnormal limb morphology
absent carpal bone
abnormal phalanx morphology
adactyly
ectrodactyly
abnormal forelimb morphology
abnormal humerus morphology
absent radius
absent ulna
absent hindlimb
abnormal limb bone morphology
abnormal limb development
absent limbs
Availability Mouse Genotype
Trp63m1Mhda/Trp63m1Mhda
Trp63tm1.1(cre)Ssig/Trp63tm1.1(cre)Ssig
Trp63tm1Aam/Trp63tm1Aam
Trp63tm1Brd/Trp63tm1Brd
Trp63tm1Fmc/Trp63tm1Fmc
Trp63tm1Sin/Trp63tm1Sin
Trp63tm2Brd/Trp63tm2Brd
Trp63tm3.2Brd/Trp63tm3.2Brd
Trp63tm1Aam/Trp63+
Tg(KRT5-cre/PGR)1Der/0
Trp63tm2Brd/Trp63tm3.1Brd  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory