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Symbol
Name
ID
Trp63
transformation related protein 63
MGI:1330810
Phenotype annotations related to integument
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Sparse and thin eyebrow
Absent eyelashes
Sparse eyelashes
Alopecia of scalp
Sparse scalp hair
Wide intermamillary distance
Absent nipple
Hypoplastic nipples
Supernumerary nipple
Breast hypoplasia
Eczema
Pili canaliculi
Patchy alopecia
Progressive alopecia
Hypotrichosis
Sparse hair
Sparse axillary hair
Sparse body hair
Sparse pubic hair
Fair hair
Coarse hair
Fine hair
Dystrophic toenail
Dystrophic fingernails
Anonychia
Small nail
Hyperconvex nail
Hyperconvex fingernails
Nail pits
Nail dystrophy
Thick nail
Decreased number of sweat glands
Anhidrosis
Hypohidrosis
Freckling
Hyperpigmentation of the skin
Generalized hyperpigmentation
Generalized hypopigmentation
Dry skin
Cutaneous photosensitivity
Ectodermal dysplasia
Anhidrotic ectodermal dysplasia
Dermal atrophy
Thin skin
Adermatoglyphia
Hyperkeratosis
Palmoplantar keratoderma
Disease(s) Associated with TP63
ADULT syndrome
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3
Rapp-Hodgkin syndrome

Mouse Phenotypes
integument phenotype
abnormal keratinocyte differentiation
decreased keratinocyte proliferation
absent mammary gland
absent sebaceous gland
impaired skin barrier function
alopecia
abnormal hair shaft morphology
abnormal hair follicle development
absent hair follicles
decreased hair follicle number
absent vibrissae
abnormal skin morphology
abnormal epidermal layer morphology
abnormal epidermis stratum basale morphology
absent epidermis stratum corneum
absent epidermis stratum granulosum
abnormal epidermis stratum spinosum morphology
absent epidermis stratum spinosum
acanthosis
abnormal keratinocyte morphology
absent epidermis
dermal-epidermal separation
blistering
shiny skin
skin lesions
spontaneous skin ulceration
translucent skin
wrinkled skin
abnormal skin condition
abnormal skin development
abnormal skin physiology
abnormal keratinocyte physiology
Availability Mouse Genotype
Trp63tm1.1(cre)Ssig/Trp63tm1.1(cre)Ssig
Trp63tm1.1Elrf/Trp63tm1.1Elrf
Trp63tm1Brd/Trp63tm1Brd
Trp63tm1Fmc/Trp63tm1Fmc
Trp63tm1Sin/Trp63tm1Sin
Trp63tm2.2Elrf/Trp63tm2.2Elrf
Trp63tm2Brd/Trp63tm2Brd
Trp63tm3.2Brd/Trp63tm3.2Brd
Trp63tm1Cmis/Trp63+
Trp63tm2.2Elrf/Trp63+
Trp63tm2Brd/Trp63+
Trp63tm1Elrf/Trp63tm1Elrf
Tg(KRT14-cre)8Brn/0  (conditional)
*
Tg(KRT5-cre/PGR)1Der/0
Trp63tm2Brd/Trp63tm3.1Brd  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory