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Symbol
Name
ID
Clcnka
chloride channel, voltage-sensitive Ka
MGI:1329026
Phenotype annotations related to homeostasis/metabolism
Darker colors indicate more annotations
Human Phenotypes
Hypokalemia
Hyponatremia
Hypochloremia
Hypokalemic hypochloremic metabolic alkalosis
Hypokalemic metabolic alkalosis
Dehydration
Edema
Hyperchloriduria
Increased urinary potassium
Renal potassium wasting
Hypernatriuria
Hypocalciuria
Renal salt wasting
Disease(s) Associated with CLCNKA
Bartter disease type 4b
Disease(s) Associated with CLCNKB
Bartter disease type 3
Bartter disease type 4b

Mouse Phenotypes
alkalemia
increased blood urea nitrogen level
increased fasting circulating glucose level
decreased circulating potassium level
hypokalemia
increased circulating renin level
improved glucose tolerance
decreased circulating chloride level
increased urine chloride ion level
increased urine potassium level
increased urine sodium level
alkalosis
abnormal urine homeostasis
increased urine magnesium level
decreased urine osmolality
increased urine prostaglandin level
decreased physiological sensitivity to xenobiotic
Availability Mouse Genotype
Clcnkatm1Suc/Clcnkatm1Suc
Clcnkbem1(IMPC)Mbp/Clcnkbem1(IMPC)Mbp
Clcnkbem1Haca/Clcnkbem1Haca
Clcnkbtm1.1Doel/Clcnkbtm1.1Doel

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory