Symbol
Name
ID

Wfs1
wolframin ER transmembrane glycoprotein
MGI:1328355

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Feeding difficulties	Feeding difficulties in infancy	Depression	Atypical behavior	Autism	Polydipsia	Polyphagia	Fatigue	Myalgia
Disease(s) Associated with WFS1	Feeding difficulties	Feeding difficulties in infancy	Depression	Atypical behavior	Autism	Polydipsia	Polyphagia	Fatigue	Myalgia
autosomal dominant Wolfram syndrome
optic atrophy
type 1 diabetes mellitus
Wolfram syndrome
Wolfram syndrome 1

Mouse Phenotypes

behavior/neurological phenotype

abnormal behavioral response to addictive substance

impaired behavioral response to addictive substance

abnormal associative learning

enhanced active avoidance behavior

enhanced passive avoidance behavior

abnormal cued conditioning behavior

decreased exploration in new environment

abnormal spatial learning

abnormal eating behavior

decreased food intake

increased coping response

increased anxiety-related response

increased thigmotaxis

abnormal postural reflex

impaired righting response

impaired coordination

impaired swimming

head bobbing

decreased vertical activity

increased vertical activity

decreased locomotor activity

increased locomotor activity

circling

analgesia

decreased copulatory plug deposition

abnormal social investigation

abnormal vocalization

Availability

Mouse Genotype

Wfs1^tm1.1Bedel/Wfs1^tm1.1Bedel

Wfs1^tm1Koks/Wfs1^tm1Koks

Wfs1^tm1Yoka/Wfs1^tm1Yoka

Wfs1^tm1Koks/Wfs1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23