Symbol
Name
ID

Men1
multiple endocrine neoplasia 1
MGI:1316736

Phenotype annotations related to craniofacial

Darker colors indicate more annotations

Human Phenotypes	Abnormality of the head	Adenoma sebaceum	Gingival fibromatosis
Disease(s) Associated with MEN1	Abnormality of the head	Adenoma sebaceum	Gingival fibromatosis
hyperparathyroidism
multiple endocrine neoplasia type 1

Mouse Phenotypes

abnormal basisphenoid bone morphology

abnormal pterygoid process morphology

abnormal craniofacial development

abnormal palatal mesenchymal cell differentiation

abnormal palatal mesenchymal cell proliferation

abnormal secondary palate development

abnormal palatal shelf bone ossification

palatal shelves fail to meet at midline

palatal shelf hypoplasia

short soft palate

cleft secondary palate

bilateral cleft palate

abnormal snout morphology

short snout

Availability

Mouse Genotype

Men1^tm1Ctre/Men1^tm1Ctre

Men1^tm1.2Ctre/Men1^tm1.2Ctre
Pax3^tm1(cre)Joe/Pax3⁺ (conditional)

Men1^tm1.2Ctre/Men1^tm1.2Ctre
Tg(Pax3-cre)1Joe/0 (conditional)

Men1^tm1.2Ctre/Men1^tm1.2Ctre
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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