Symbol
Name
ID

Slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
MGI:1315204

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Elevated transferrin saturation	Increased circulating ferritin concentration	Glucose intolerance	Diabetes mellitus	Impaired glucose tolerance	Hepatic steatosis
Disease(s) Associated with SLC40A1
hemochromatosis type 4

Mouse Phenotypes

homeostasis/metabolism phenotype

increased heart iron level

decreased intestinal iron level

increased intestinal iron level

increased pancreas iron level

decreased spleen iron level

increased spleen iron level

increased circulating triglyceride level

decreased circulating iron level

increased circulating iron level

increased circulating lipase level

increased circulating ferritin level

decreased circulating unsaturated transferrin level

increased circulating unsaturated transferrin level

abnormal enzyme/coenzyme level

edema

abnormal iron homeostasis

increased brain iron level

increased kidney iron level

abnormal liver iron level

decreased liver iron level

increased liver iron level

hemochromatosis

Availability

Mouse Genotype

Slc40a1^ffe/Slc40a1^ffe

Slc40a1^Pcm/Slc40a1^Pcm

Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe

Slc40a1^ffe/Slc40a1⁺

Slc40a1^Pcm/Slc40a1⁺

Slc40a1^tm1.1Mmfe/Slc40a1⁺

Slc40a1^{tm1b(EUCOMM)Hmgu}/Slc40a1⁺

Slc40a1^tm1Nca/Slc40a1⁺

Meox2^tm1(cre)Sor/Meox2⁺
Slc40a1^tm2Nca/Slc40a1^tm2Nca (conditional)

Slc40a1^tm2Nca/Slc40a1^tm2Nca
Tg(Vil1-cre/ERT2)23Syr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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