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Symbol
Name
ID
Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
MGI:1314884
Phenotype annotations related to homeostasis/metabolism
Darker colors indicate more annotations
Human Phenotypes
Periorbital edema
Elevated C-reactive protein level
Elevated erythrocyte sedimentation rate
Recurrent fever
Hepatic amyloidosis
Disease(s) Associated with TNFRSF1A
autosomal dominant familial periodic fever

Mouse Phenotypes
decreased susceptibility to dopaminergic neuron neurotoxicity
impaired adaptive thermogenesis
decreased circulating calcium level
decreased circulating interleukin-1 beta level
decreased circulating interleukin-6 level
increased circulating tumor necrosis factor level
decreased circulating alanine transaminase level
increased circulating alanine transaminase level
decreased circulating total protein level
impaired skin barrier function
abnormal response/metabolism to endogenous compounds
decreased sensitivity to xenobiotic induced morbidity/mortality
decreased physiological sensitivity to xenobiotic
Availability Mouse Genotype
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tnfrsf1atm1Rsie/Tnfrsf1atm1Rsie
Tnfrsf1atm2.1Rsie/Tnfrsf1atm2.1Rsie
Tnfrsf1atm2b(EUCOMM)Wtsi/Tnfrsf1atm2b(EUCOMM)Wtsi
Tnfrsf1atm1Blt/Tnfrsf1a+
Tnfrsf1atm1Imx/Tnfrsf1a+
Tnfrsf1atm1Mak/Tnfrsf1a+
Tnfrsf1atm1Rsie/Tnfrsf1a+
Tnfrsf1atm2.1Rsie/Tnfrsf1a+
Tnfrsf1atm3.1Gkl/Tnfrsf1atm3.1Gkl
Tg(Vil1-cre)997Gum/0  (conditional)
Tnfrsf1atm3.1Gkl/Tnfrsf1a+
Tg(Vil1-cre)997Gum/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory