Symbol
Name
ID

Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
MGI:1314884

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Periorbital edema	Elevated C-reactive protein level	Elevated erythrocyte sedimentation rate	Recurrent fever	Hepatic amyloidosis
Disease(s) Associated with TNFRSF1A
autosomal dominant familial periodic fever

Mouse Phenotypes

decreased susceptibility to dopaminergic neuron neurotoxicity

impaired adaptive thermogenesis

decreased circulating calcium level

decreased circulating interleukin-1 beta level

decreased circulating interleukin-6 level

increased circulating tumor necrosis factor level

decreased circulating alanine transaminase level

increased circulating alanine transaminase level

decreased circulating total protein level

impaired skin barrier function

abnormal response/metabolism to endogenous compounds

decreased sensitivity to xenobiotic induced morbidity/mortality

decreased physiological sensitivity to xenobiotic

Availability

Mouse Genotype

Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt

Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx

Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak

Tnfrsf1a^tm1Rsie/Tnfrsf1a^tm1Rsie

Tnfrsf1a^tm2.1Rsie/Tnfrsf1a^tm2.1Rsie

Tnfrsf1a^{tm2b(EUCOMM)Wtsi}/Tnfrsf1a^{tm2b(EUCOMM)Wtsi}

Tnfrsf1a^tm1Blt/Tnfrsf1a⁺

Tnfrsf1a^tm1Imx/Tnfrsf1a⁺

Tnfrsf1a^tm1Mak/Tnfrsf1a⁺

Tnfrsf1a^tm1Rsie/Tnfrsf1a⁺

Tnfrsf1a^tm2.1Rsie/Tnfrsf1a⁺

Tnfrsf1a^tm3.1Gkl/Tnfrsf1a^tm3.1Gkl
Tg(Vil1-cre)997Gum/0 (conditional)

Tnfrsf1a^tm3.1Gkl/Tnfrsf1a⁺
Tg(Vil1-cre)997Gum/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16