Symbol
Name
ID

Lrp6
low density lipoprotein receptor-related protein 6
MGI:1298218

Phenotype annotations related to skeleton

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Aplasia of the maxilla	Enamel hypoplasia
Disease(s) Associated with LRP6	Aplasia of the maxilla	Enamel hypoplasia
tooth agenesis

Mouse Phenotypes

skeleton phenotype

abnormal cranium morphology

small cranium

abnormal frontal bone morphology

thin neurocranium

small lower incisors

long upper incisors

short incisors

abnormal molar cusp morphology

decreased molar number

small molars

abnormal tooth development

abnormal tooth eruption

growth retardation of molars

spina bifida occulta

abnormal caudal vertebrae morphology

caudal vertebral fusion

small caudal vertebrae

rib fusion

abnormal vertebrae morphology

abnormal lumbar vertebrae morphology

abnormal sacral vertebrae morphology

abnormal vertebrae development

abnormal vertebral arch morphology

absent vertebrae

hemivertebra

vertebral fusion

decreased bone mineral density

osteoporosis

delayed cranial suture closure

delayed bone ossification

Availability

Mouse Genotype

Lrp6^Cd/Lrp6^Cd

Lrp6^Gt(Ex187)Byg/Lrp6^Gt(Ex187)Byg

Lrp6^rs/Lrp6^rs

Lrp6^Cd/Lrp6⁺

Lrp6^Cd/Lrp6^Gt(Ex187)Byg

Lrp6^Gt(Ex187)Byg/Lrp6⁺

Lrp6^tm1.1Vari/Lrp6^tm1.1Vari
Twist2^tm1(cre)Dor/Twist2⁺ (conditional)

Lrp6^tm1.1Vari/Lrp6^tm1.2Vari
Twist2^tm1(cre)Dor/Twist2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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