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Symbol
Name
ID
Lrp5
low density lipoprotein receptor-related protein 5
MGI:1278315
Phenotype annotations related to skeleton
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Mandibular prognathia
Craniofacial hyperostosis
Microcephaly
Frontal bossing
Wormian bones
Thickened calvaria
Diaphyseal thickening
Metatarsal diaphyseal endosteal sclerosis
Abnormal lower limb bone morphology
Abnormality of the femoral neck or head region
Metacarpal diaphyseal endosteal sclerosis
Metaphyseal widening
Crumpled long bones
Thickened cortex of long bones
Abnormality of pelvic girdle bone morphology
Clavicular sclerosis
Abnormality of the ribs
Barrel-shaped chest
Abnormality of the vertebral column
Abnormal form of the vertebral bodies
Platyspondyly
Sclerotic vertebral body
Kyphoscoliosis
Generalized osteosclerosis
Osteopetrosis
Osteopenia
Osteoporosis
Abnormal cortical bone morphology
Hyperostosis
Joint hypermobility
Joint laxity
Increased susceptibility to fractures
Pathologic fracture
Recurrent fractures
Disease(s) Associated with LRP5
autosomal dominant endosteal hyperostosis
autosomal dominant osteopetrosis 1
exudative vitreoretinopathy 1
exudative vitreoretinopathy 4
osteoporosis
osteoporosis-pseudoglioma syndrome
Worth's syndrome

Mouse Phenotypes
skeleton phenotype
decreased osteoblast proliferation
abnormal osteoblast physiology
thin parietal bone
decreased osteoclast cell number
abnormal phalanx morphology
abnormal femur morphology
decreased diameter of femur
decreased diameter of tibia
abnormal long bone diaphysis morphology
abnormal lumbar vertebrae morphology
abnormal bone structure
decreased bone mineral content
decreased areal bone mineral density
decreased bone mineral density
decreased bone volume
decreased compact bone mass
decreased osteoblast cell number
abnormal trabecular bone morphology
abnormal bone trabecula morphology
decreased trabecular bone mass
decreased bone mass
osteoporosis
increased bone mass
abnormal bone ossification
abnormal bone mineralization
decreased bone mineralization
decreased bone ossification
delayed bone ossification
increased bone ossification
decreased bone resorption
decreased bone stiffness
decreased bone strength
Availability Mouse Genotype
Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Lrp5tm1.1Mawa/Lrp5tm1.1Mawa
Lrp5tm1.2Vari/Lrp5tm1.2Vari *
Lrp5tm1Grw/Lrp5tm1Grw
Lrp5tm1Jfh/Lrp5tm1Jfh
Lrp5tm1Jsak/Lrp5tm1Jsak
Lrp5tm1Kry/Lrp5tm1Kry *
Lrp5tm1Lex/Lrp5tm1Lex
Lrp5tm2.1Mawa/Lrp5tm2.1Mawa
Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Lrp5tvrm111B/Lrp5tvrm111B
Lrp5tm1.1Mawa/Lrp5+
Lrp5tm1Kry/Lrp5+
Lrp5tm1Lex/Lrp5+
Lrp5tm1Mawa/Lrp5+ *
Lrp5tm2.1Mawa/Lrp5+
Lrp5tm2Mawa/Lrp5+ *
Lrp5tm2Kry/Lrp5tm2Kry
Tg(Col1a1-cre)1Kry/0  (conditional)
*
Lrp5tm2Kry/Lrp5tm2Kry
Tg(Vil1-cre)20Syr/0  (conditional)
Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Vil1-cre)20Syr/0  (conditional)
Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Col1a1-cre)1Kry/0  (conditional)
*
Lrp5tm3.1Mawa/Lrp5tm3.1Mawa
Tg(Dmp1-cre)1Jqfe/0  (conditional)
Lrp5tm3.1Mawa/Lrp5tm3.1Mawa
Tg(Vil1-cre)997Gum/0  (conditional)
*
Lrp5tm1.1Vari/Lrp5tm1.2Vari
Twist2tm1(cre)Dor/Twist2+  (conditional)
*
Lrp5tm1Mawa/Lrp5+
Tg(Dmp1-cre)1Jqfe/0  (conditional)
Lrp5tm1Mawa/Lrp5+
Tg(Vil1-cre)997Gum/0  (conditional)
*
Lrp5tm1Mawa/Lrp5+
Tg(Prrx1-cre)1Cjt/0  (conditional)
Lrp5tm2Kry/Lrp5+
Tg(Vil1-cre)20Syr/0  (conditional)
Lrp5tm2Mawa/Lrp5+
Tg(Dmp1-cre)1Jqfe/0  (conditional)
Lrp5tm2Mawa/Lrp5+
Tg(Vil1-cre)997Gum/0  (conditional)
*
Lrp5tm2Mawa/Lrp5+
Tg(Prrx1-cre)1Cjt/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory