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Symbol
Name
ID
Lrp5
low density lipoprotein receptor-related protein 5
MGI:1278315
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Facial palsy
Glioma
Intellectual disability, mild
Loss of ability to walk
Waddling gait
Headache
Delayed speech and language development
Global developmental delay
Delayed gross motor development
Disease(s) Associated with LRP5
autosomal dominant endosteal hyperostosis
autosomal dominant osteopetrosis 1
osteoporosis-pseudoglioma syndrome

Mouse Phenotypes
abnormal serotonin level
decreased serotonin level
increased serotonin level
gliosis
retinal ganglion cell degeneration
retinal photoreceptor degeneration
abnormal blood-retinal barrier function
Availability Mouse Genotype
Lrp5tm1Dgen/Lrp5tm1Dgen
Lrp5tm1Kry/Lrp5tm1Kry
Lrp5tvrm111B/Lrp5tvrm111B
Lrp5tm1Kry/Lrp5+
Lrp5tm2Kry/Lrp5tm2Kry
Tg(Vil1-cre)20Syr/0  (conditional)
Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Vil1-cre)20Syr/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory