|
Symbol Name ID |
Lrp5
low density lipoprotein receptor-related protein 5 MGI:1278315 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Elevated serum acid phosphatase |
Increased total bilirubin |
Elevated circulating creatinine concentration |
Elevated circulating alkaline phosphatase concentration |
Low serum calcitriol |
Abnormal urinary electrolyte concentration |
Hematuria |
Albuminuria |
Ascites |
Retinal calcification |
| Disease(s) Associated with LRP5 | ||||||||||
| autosomal dominant osteopetrosis 1 | ||||||||||
| autosomal dominant polycystic kidney disease | ||||||||||
| osteoporosis-pseudoglioma syndrome | ||||||||||
| polycystic liver disease |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
decreased insulin secretion |
decreased circulating insulin level |
increased circulating VLDL cholesterol level |
impaired glucose tolerance |
insulin resistance |
abnormal serotonin level |
decreased serotonin level |
increased serotonin level |
abnormal calcium ion homeostasis |
increased cholesterol level |
|
| Availability | Mouse Genotype | |||||||||||
| Lrp5tm1Jsak/Lrp5tm1Jsak | ||||||||||||
| Lrp5tm1Kry/Lrp5tm1Kry | ||||||||||||
| Lrp5tm1Jsak/Lrp5+ | ||||||||||||
| Lrp5tm1Kry/Lrp5+ | ||||||||||||
| Lrp5tm2Kry/Lrp5tm2Kry Tg(Col1a1-cre)1Kry/0 (conditional) |
* | |||||||||||
| Lrp5tm2Kry/Lrp5tm2Kry Tg(Vil1-cre)20Syr/0 (conditional) |
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| Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry Tg(Vil1-cre)20Syr/0 (conditional) |
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| Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry Tg(Col1a1-cre)1Kry/0 (conditional) |
* | |||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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