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Symbol
Name
ID
Lrp5
low density lipoprotein receptor-related protein 5
MGI:1278315
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Low serum calcitriol
Disease(s) Associated with LRP5
osteoporosis-pseudoglioma syndrome

Mouse Phenotypes
homeostasis/metabolism phenotype
decreased insulin secretion
decreased circulating insulin level
increased circulating VLDL cholesterol level
impaired glucose tolerance
insulin resistance
abnormal serotonin level
decreased serotonin level
increased serotonin level
abnormal calcium ion homeostasis
increased cholesterol level
Availability Mouse Genotype
Lrp5tm1Jsak/Lrp5tm1Jsak
Lrp5tm1Kry/Lrp5tm1Kry
Lrp5tm1Jsak/Lrp5+
Lrp5tm1Kry/Lrp5+
Lrp5tm2Kry/Lrp5tm2Kry
Tg(Col1a1-cre)1Kry/0  (conditional)
*
Lrp5tm2Kry/Lrp5tm2Kry
Tg(Vil1-cre)20Syr/0  (conditional)
Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Vil1-cre)20Syr/0  (conditional)
Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Col1a1-cre)1Kry/0  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory