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cyclin-dependent kinase 6
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
decreased thymocyte apoptosis
increased T cell apoptosis
decreased T cell proliferation
abnormal thymus morphology
thymus cortex atrophy
enlarged thymus
small thymus
thymus atrophy
thymus hypoplasia
decreased thymocyte number
decreased DN1 thymic pro-T cell number
decreased DN2 thymocyte number
decreased DN4 thymocyte number
increased thymocyte number
increased DN1 thymic pro-T cell number
increased DN3 thymocyte number
abnormal thymocyte activation
abnormal lymphopoiesis
abnormal T cell differentiation
decreased double-negative T cell number
increased double-negative T cell number
decreased double-positive T cell number
increased CD4-positive, alpha beta T cell number
decreased CD8-positive, alpha-beta T cell number
increased CD8-positive, alpha-beta T cell number
increased single-positive T cell number
decreased leukocyte cell number
abnormal spleen morphology
abnormal spleen red pulp morphology
small spleen
spleen hypoplasia
Availability Mouse Genotype
Cdk6tm1.1Phin/Cdk6tm1.1Phin *
Cdk6tm1Phin/Cdk6tm1Phin *
Cdk6tm3.1Phin/Cdk6tm3.1Phin *
Cdk6tm4.1Phin/Cdk6tm4.1Phin *

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory