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Symbol
Name
ID
Ep300
E1A binding protein p300
MGI:1276116
Phenotype annotations related to immune system
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Leukemia
Recurrent upper respiratory tract infections
Polysplenia
Recurrent infections
Disease(s) Associated with EP300
Rubinstein-Taybi syndrome

Mouse Phenotypes
arteritis
increased B cell apoptosis
decreased B cell proliferation
small thymus
decreased thymocyte number
abnormal B cell differentiation
abnormal transitional stage B cell morphology
increased double-positive T cell number
decreased eosinophil cell number
decreased marginal zone B cell number
decreased B cell number
increased B cell number
decreased single-positive T cell number
increased activated T cell number
decreased lymphocyte cell number
decreased leukocyte cell number
abnormal spleen marginal zone macrophage morphology
intermingled spleen red and white pulp
increased spleen weight
enlarged spleen
increased IgG2b level
increased immunoglobulin level
enlarged lymph nodes
abnormal adaptive immunity
abnormal humoral immune response
increased susceptibility to systemic lupus erythematosus
increased anti-double stranded DNA antibody level
kidney inflammation
glomerulonephritis
Availability Mouse Genotype
Ep300Plt6/Ep300Plt6
Ep300tm1Pkb/Ep300tm1Pkb
Ep300tm2Pkb/Ep300tm2Pkb
Tg(Lck-cre)548Jxm/0  (conditional)
Cd19tm1(cre)Cgn/Cd19+
Ep300tm2Reck/Ep300+  (conditional)
!

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory