Symbol
Name
ID

Casp8
caspase 8
MGI:1261423

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Reduced CD95-induced lymphocyte apoptosis	Decreased circulating IgA level	Decreased circulating IgG level	Decreased circulating total IgM	Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vaccine	Defective B cell activation	Decreased T cell activation	Elevated circulating hepatic transaminase concentration	Diabetes mellitus
Disease(s) Associated with CASP8	Reduced CD95-induced lymphocyte apoptosis	Decreased circulating IgA level	Decreased circulating IgG level	Decreased circulating total IgM		Defective B cell activation	Decreased T cell activation	Elevated circulating hepatic transaminase concentration	Diabetes mellitus
autoimmune lymphoproliferative syndrome type 2B
pancreatic cancer

Mouse Phenotypes

hemopericardium

pericardial edema

abnormal circulating enzyme level

decreased circulating alanine transaminase level

decreased circulating aspartate transaminase level

skin edema

epidermal spongiosis

impaired skin barrier function

abnormal response/metabolism to endogenous compounds

decreased susceptibility to injury

increased susceptibility to injury

Availability

Mouse Genotype

Casp8^em1Hbz/Casp8^em1Hbz

Casp8^tm1Syon/Casp8^tm1Syon

Casp8^tm1Clie/Casp8^tm1Clie
Tg(Alb1-cre)7Gsc/0 (conditional)

Casp8^tm1Hed/Casp8^tm1Hed
Tg(KRT14-cre)1Efu/0 (conditional)

Casp8^tm1Wll/Casp8^tm1.1Yuan
Tg(Alb1-cre)7Gsc/0 (conditional)

Casp8^tm1Wll/Casp8^tm1.1Yuan
Tg(Tie1-cre)9Ref/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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