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Symbol
Name
ID
Casp8
caspase 8
MGI:1261423
Phenotype annotations related to cellular
Darker colors indicate more annotations
Human Phenotypes
Defective B cell activation
Decreased T cell activation
Disease(s) Associated with CASP8
autoimmune lymphoproliferative syndrome type 2B

Mouse Phenotypes
myocardium necrosis
increased cardiomyocyte apoptosis
abnormal cell death
decreased T cell apoptosis
increased apoptosis
abnormal macrophage differentiation
decreased B cell proliferation
abnormal T cell proliferation
decreased T cell proliferation
Availability Mouse Genotype
Casp8tm1Syon/Casp8tm1Syon
Casp8tm1Yuan/Casp8tm1Yuan
Casp8tm1Hed/Casp8tm1Hed
Cd19tm1(cre)Cgn/Cd19+  (conditional)
Casp8tm1Raz/Casp8tm1Raz
Tg(Lck-cre)548Jxm/0  (conditional)
Casp8tm1Wll/Casp8tm1.1Yuan
Tg(Tie1-cre)9Ref/0  (conditional)
Casp8tm1Wll/Casp8tm1.1Yuan
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory