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Symbol Name ID |
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha MGI:1206581 |
| Darker colors indicate more annotations |
| Human Phenotypes | Palmoplantar hyperkeratosis |
Gynecomastia |
Breast carcinoma |
Melanocytic nevus |
Subcutaneous lipoma |
Capillary malformation |
Epidermal nevus |
Numerous nevi |
Skin tags |
Seborrheic keratosis |
| Disease(s) Associated with PIK3CA | ||||||||||
| breast cancer | ||||||||||
| CLOVES syndrome | ||||||||||
| Cowden syndrome 5 | ||||||||||
| epidermal nevus | ||||||||||
| ovarian cancer | ||||||||||
| seborrheic keratosis |
| Mouse Phenotypes | increased mammary gland epithelial cell proliferation |
abnormal branching of the mammary ductal tree |
abnormal mammary gland epithelium morphology |
abnormal mammary gland duct morphology |
abnormal mammary duct terminal end bud morphology |
abnormal mammary gland myoepithelium morphology |
abnormal mammary gland stroma morphology |
increased mammary gland tumor incidence |
increased fibroadenoma incidence |
increased mammary adenocarcinoma incidence |
increased mammary adenoacanthoma incidence |
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| Availability | Mouse Genotype | |||||||||||
| Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ Tg(MMTV-cre)1Mam/0 (conditional) |
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| Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ Tg(MMTV-cre)#Tfln/0 (conditional) |
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| Pik3catm1.1Waph/Pik3ca+ Tg(MMTV-cre)#Mam/0 (conditional) |
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| Pik3catm1Gne/Pik3ca+ Tg(MMTV-cre)1Mam/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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