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Symbol
Name
ID
Smad3
SMAD family member 3
MGI:1201674
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Camptodactyly
Retrognathia
Malar flattening
Craniosynostosis
Dolichocephaly
Arachnodactyly
Protrusio acetabuli
Knee osteoarthritis
Abnormality of the sternum
Cervical spine instability
Scoliosis
Intervertebral disc degeneration
Spondylolisthesis
Osteoporosis
Hip osteoarthritis
Osteochondritis Dissecans
Joint laxity
Disease(s) Associated with SMAD3
Loeys-Dietz syndrome 3

Mouse Phenotypes
osteoarthritis
abnormal carpal bone morphology
abnormal tarsal bone morphology
abnormal talus morphology
increased width of hypertrophic chondrocyte zone
abnormal sternum morphology
abnormal thoracic cage morphology
abnormal rib morphology
kyphoscoliosis
kyphosis
decreased bone mineral density
abnormal cartilage morphology
abnormal chondrocyte morphology
abnormal articular cartilage morphology
abnormal joint morphology
abnormal synovial joint capsule morphology
calcified joint
abnormal epiphyseal plate morphology
abnormal skeleton physiology
Availability Mouse Genotype
Smad3tm1Cxd/Smad3tm1Cxd
Smad3tm1Xfw/Smad3tm1Xfw

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory